Tyre defect with all-wheel drive – What must be replaced ?

Hello, I have now with my A3 Sportback all-wheel a tire damage (nail) , 4 year old Michelin summer tires (reversed with winter tires) . If the tire should not be repairable . What do I have to replace ? 1 tires : get then problems on the axle , because of different tire diameter between old and new tires on the same axle ? Or 2 tires on the axle ? or even all 4 tires (believe / hope I do not now ) ? Greeting apollo