Poles on the rear axle

Hello w116 Community I’ve been on my 280se bj1979 with 286000 km a poltern or knock at the HA for several days. Especially to remember it was when I put about 70kg in the trunk and drove off. Easy knocking while accelerating but then at about 50-60kmh to drive into a left curve it was threateningly loud these poltern. When driving just out it was clearly quieter to almost not at all to hear. When I took the weight out again it was hardly to be heard. Has someone had such a phenomenon before? Would be grateful for any hint. Greetings Robert